Corpus ID: 203562617

In vitro Antiproliferative Characteristics of Flavonoids and Diazepam on MDA-MB-231 Breast Cancer Cells

@inproceedings{Kim2010InVA,
  title={In vitro Antiproliferative Characteristics of Flavonoids and Diazepam on MDA-MB-231 Breast Cancer Cells},
  author={J. Kim and M. Lee and J. Lee and Jeoung-Hee Ha},
  year={2010}
}
The beneficial use of sedatives is often required for medically ill patients. This study examined the effect of plant flavonoids and diazepam peripheral-type benzodiazepine receptor (PBR) activation and glucose utilization in breast cancer cells, along with their interactions. In estrogen receptor negative MDA-MB-231 cells, the anti-proliferative activity of fisetin (3,7,3',4'-tetrahydroxyflavone) and diazepam was more prominent than in estrogen receptor positive MCF-7 cells. Unlike PBR ligands… Expand

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