In vitro Anti‐human Immunodeficiency Virus Type 1 Activity of Biliverdin, a Bile Pigment

@inproceedings{Mori1991InVA,
  title={In vitro Anti‐human Immunodeficiency Virus Type 1 Activity of Biliverdin, a Bile Pigment},
  author={Haruyo Mori and Toru Otake and Motoko Morimoto and Noboru Ueba and Nobuharu Kunita and Tatsuyoshi Nakagami and Non Yamasaki and Shiro Taji},
  booktitle={Japanese journal of cancer research : Gann},
  year={1991}
}
Biliverdin (BV) is a bile pigment having anti-allergic properties. We examined the effect of BV on human immunodeficiency virus type 1 (HIV-1) in vitro. BV completely inhibited the cytopathic effect of HIV-1 in MT-4 cells at concentrations of 22.2 micrograms/ml or more. This inhibitory effect was also observed when BV was present during the adsorption period of HIV-1. However, BV was cytotoxic to MT-4 cells at concentrations above 800 micrograms/ml. At a concentration of 66.7 micrograms/ml, BV… CONTINUE READING