In vitro 3D collective sprouting angiogenesis under orchestrated ANG-1 and VEGF gradients.

@article{Shin2011InV3,
  title={In vitro 3D collective sprouting angiogenesis under orchestrated ANG-1 and VEGF gradients.},
  author={Yoojin Shin and J. S. Jeon and Sewoon Han and Gi-Seok Jung and Sehyun Shin and Sang-Hoon Lee and Ryo Sudo and Roger D Kamm and Seok Hyun Chung},
  journal={Lab on a chip},
  year={2011},
  volume={11 13},
  pages={2175-81}
}
Sprouting angiogenesis requires a coordinated guidance from a variety of angiogenic factors. Here, we have developed a unique hydrogel incorporating microfluidic platform which mimics the physiological microenvironment in 3D under a precisely orchestrated gradient of soluble angiogenic factors, VEGF and ANG-1. The system enables the quantified investigation in chemotactic response of endothelial cells during the collective angiogenic sprouting process. While the presence of a VEGF gradient… CONTINUE READING

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