In vitro (CTG)*(CAG) expansions and deletions by human cell extracts.

  title={In vitro (CTG)*(CAG) expansions and deletions by human cell extracts.},
  author={G. Panigrahi and John Douglas Cleary and Christopher E. Pearson},
  journal={The Journal of biological chemistry},
  volume={277 16},
The mechanism of disease-associated (CTG)*(CAG) expansion may involve DNA replication slippage, replication direction, Okazaki fragment processing, recombination, or repair. A length-dependent bias for expansions is observed in humans affected by a trinucleotide repeat-associated disease. We developed an assay to test the effect of replication direction on (CTG)*(CAG) instabilities incurred during in vitro (SV40) DNA replication mediated by human cell extracts. This system recapitulates the… CONTINUE READING


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