In vitro–in vivo and pharmacokinetic evaluation of solid lipid nanoparticles of furosemide using Gastroplus™

  title={In vitro–in vivo and pharmacokinetic evaluation of solid lipid nanoparticles of furosemide using Gastroplus{\texttrademark}},
  author={H. Ali and P. Verma and S. Dubey and J. Venkatesan and Young-Hwan Seo and Se-kwon Kim and S. Singh},
  journal={RSC Advances},
In this work, we conducted pharmacokinetic studies and established the in vitro and in vivo correlation (IVIVC) of furosemide (FRS) loaded solid lipid nanoparticles (FSLN). A bioanalytical method using RP-HPLC was developed and validated to evaluate the pharmacokinetic properties of FSLN and FRS suspension (FSP). The pharmacokinetic parameters were analyzed using various pharmacokinetic compartment models (one, two and three) and non-compartmental analysis. The IVIVC was accomplished using… Expand

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