In vitro–in situ permeability and dissolution of fexofenadine with kinetic modeling in the presence of sodium dodecyl sulfate

  title={In vitro–in situ permeability and dissolution of fexofenadine with kinetic modeling in the presence of sodium dodecyl sulfate},
  author={Evren Gundogdu and V{\'i}ctor Mangas-Sanju{\'a}n and Isabel Gonz{\'a}lez-{\'A}lvarez and Marival Bermejo and Ercument Karasulu},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
The purpose of this study was to estimate passive permeability and efflux transport parameters of fexofenadine (FEX) from in vitro cell culture and in situ rat experiments and determine the dissolution profile of FEX in the absence and presence of sodium dodecyl sulfate (SDS). The dissolution rate of FEX was investigated at different pH values and in the presence of SDS. The permeability of FEX was determined in situ in small intestine of Wistar rats and in vitro in Caco-2 cell monolayer… 

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  • B. RegeJ. KaoJ. Polli
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    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2002

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