In vitro–in situ permeability and dissolution of fexofenadine with kinetic modeling in the presence of sodium dodecyl sulfate

@article{Gundogdu2011InVS,
  title={In vitro–in situ permeability and dissolution of fexofenadine with kinetic modeling in the presence of sodium dodecyl sulfate},
  author={E. Gundogdu and V. Mangas-Sanju{\'a}n and I. Gonz{\'a}lez-{\'A}lvarez and M. Bermejo and E. Karasulu},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={2011},
  volume={37},
  pages={65-75}
}
The purpose of this study was to estimate passive permeability and efflux transport parameters of fexofenadine (FEX) from in vitro cell culture and in situ rat experiments and determine the dissolution profile of FEX in the absence and presence of sodium dodecyl sulfate (SDS). The dissolution rate of FEX was investigated at different pH values and in the presence of SDS. The permeability of FEX was determined in situ in small intestine of Wistar rats and in vitro in Caco-2 cell monolayer… Expand
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