In vasculitis of small muscular arteries, activation of vessel-infiltrating CD8 T cells seems to be antigen-independent


The etiology of polyarteritis nodosa (PAN) and localized PAN is still unknown, although a T cell-mediated immune mechanism has been considered. CD8 T cells participate not only in the antigen-dependent adaptive immune system, but also in the antigen-independent innate immune system. Non-antigen-activated CD8 T cells express a unique phenotype: granzyme B… (More)
DOI: 10.1007/s00428-017-2264-2


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