In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism

  title={In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism},
  author={Elizabeth J Radford and Mitsuteru Ito and Hui Shi and Jennifer A. Corish and Kazuki Yamazawa and Elvira Isganaitis and Stefanie Seisenberger and Timothy Alexander Hore and Wolf Reik and Serap Erkek and Antoine H F M Peters and Mary Elizabeth Patti and Anne C Ferguson-Smith},
Adverse prenatal environments can promote metabolic disease in offspring and subsequent generations. Animal models and epidemiological data implicate epigenetic inheritance, but the mechanisms remain unknown. In an intergenerational developmental programming model affecting F2 mouse metabolism, we demonstrate that the in utero nutritional environment of F1 embryos alters the germline DNA methylome of F1 adult males in a locus-specific manner. Differentially methylated regions are hypomethylated… CONTINUE READING


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