In utero transfer and expression of exogenous genes in sheep.

  title={In utero transfer and expression of exogenous genes in sheep.},
  author={Nam D. Tran and Christopher D. Porada and Yongjun Zhao and Graça Almeida-Porada and W. French Anderson and Esmail D. Zanjani},
  journal={Experimental hematology},
  volume={28 1},
OBJECTIVE We have previously reported that directly injecting low-titer retroviral vector supernatant into pre-immune sheep fetuses resulted in the transfer and long-term expression of the bacterial NeoR gene within the hematopoietic system of these animals for over 5 years. In the present studies, we investigated whether using a higher titer vector would enable more efficient transduction and expression of the transgenes within the hematopoetic cells in sheep injected in utero. MATERIALS AND… CONTINUE READING

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