In utero surgery rescues neurological function at birth in sheep with spina bifida

  title={In utero surgery rescues neurological function at birth in sheep with spina bifida},
  author={M. Meuli and C. Meuli-Simmen and G. Hutchins and C. Yingling and K. M. Hoffman and M. Harrison and N. Adzick},
  journal={Nature Medicine},
  • M. Meuli, C. Meuli-Simmen, +4 authors N. Adzick
  • Published 1995
  • Medicine
  • Nature Medicine
  • We hypothesize that the neurologic deficit associated with open spina bifida is not directly caused by the primary defect but rather is due to chronic mechanical and chemical trauma since the unprotected neural tissue is exposed to the intrauterine environment. We report here that exposure of the normal spinal cord to the amniotic cavity in midgestational sheep fetuses leads to a human-like open spina bifida with paraplegia at birth, indicating that the exposed neural tissue is progressively… CONTINUE READING
    274 Citations

    Paper Mentions

    Spina bifida (myelomeningocele) is a complex birth defect in which a portion of the spinal cord is not fully developed. The overlying bones and skin are incompletely formed and the… Expand
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