In utero surgery rescues neurological function at birth in sheep with spina bifida

@article{Meuli1995InUS,
  title={In utero surgery rescues neurological function at birth in sheep with spina bifida},
  author={Martin Meuli and Claudia Meuli‐Simmen and Grover M. Hutchins and Charles D. Yingling and K M Hoffman and Michael R. Harrison and N.S. Adzick},
  journal={Nature Medicine},
  year={1995},
  volume={1},
  pages={342-347}
}
We hypothesize that the neurologic deficit associated with open spina bifida is not directly caused by the primary defect but rather is due to chronic mechanical and chemical trauma since the unprotected neural tissue is exposed to the intrauterine environment. We report here that exposure of the normal spinal cord to the amniotic cavity in midgestational sheep fetuses leads to a human-like open spina bifida with paraplegia at birth, indicating that the exposed neural tissue is progressively… Expand

Paper Mentions

Interventional Clinical Trial
Spina bifida (myelomeningocele) is a complex birth defect in which a portion of the spinal cord is not fully developed. The overlying bones and skin are incompletely formed and the… Expand
ConditionsMeningomyelocele, Spinal Dysraphism
InterventionProcedure
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  • Medicine
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