In utero stem cell transplantation for radical treatment of osteogenesis imperfecta: perspectives and controversies.


Osteogenesis imperfecta (OI) is a lethal hereditary connective tissue disease that affects the synthesis of type I collagen. Current treatment options including surgical, physical, and medical treatment help to reduce pain, deformities, and rate of bone fracture. However, these choices are insufficient and are associated with many adverse effects. The… (More)
DOI: 10.1055/s-0033-1363501


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