In utero origins of childhood leukaemia.

  title={In utero origins of childhood leukaemia.},
  author={Mel F. Greaves},
  journal={Early human development},
  volume={81 1},
Chimaeric fusion genes derived by chromosome translocation are common molecular abnormalities in paediatric leukaemia and provide unique markers for the malignant clone. They have been especially informative in studies with twins concordant for leukaemia and in retrospective scrutiny of archived neonatal blood spots. These data have indicated that, in paediatric leukaemia, the majority of chromosome translocations arise in utero during foetal haemopoiesis. Chromosomal translocations and… CONTINUE READING

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