In utero hematopoietic stem cell transplantation: progress toward clinical application.

@article{Merianos2008InUH,
  title={In utero hematopoietic stem cell transplantation: progress toward clinical application.},
  author={Demetri J Merianos and Todd E Heaton and Alan W. Flake},
  journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation},
  year={2008},
  volume={14 7},
  pages={729-40}
}
In utero hematopoietic stem cell transplantation (IUHCT) is a potential therapeutic alternative to postnatal hematopoietic stem cell transplantation (HSCT) for congenital hematologic disorders that can be diagnosed early in gestation and can be cured by HSCT. The rationale is to take advantage of normal events during hematopoietic and immunologic ontogeny to facilitate allogeneic hematopoietic engraftment. Although the rationale remains compelling, IUHCT has not yet achieved its clinical… CONTINUE READING

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In utero hematopoietic cell transplantation using haploidentical parental donors reverses the lethal phenotype in dogs with canine leukocyte adhesion deficiency

  • WH Peranteau, Y Gu, S Volk
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  • 2006
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