In utero exposure to immunosuppressive drugs: experimental and clinical studies

@article{Tendron2002InUE,
  title={In utero exposure to immunosuppressive drugs: experimental and clinical studies},
  author={Anaı¨s Tendron and J.-B. Gouyon and St{\'e}phane Decramer},
  journal={Pediatric Nephrology},
  year={2002},
  volume={17},
  pages={121-130}
}
Over the last few decades, the number of pregnant women under immunosuppressive (IS) therapy following transplantation or autoimmune diseases has increased. At first, IS drugs, including prednisone, azathioprine, and cyclosporine A were used, but now new molecules such as tacrolimus and mycophenolate mofetil have appeared. These IS drugs cross the placental barrier and enter into the fetal circulation, which poses a risk for fetal development. Experimental data have shown that IS drugs often… CONTINUE READING

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