In utero and lactation exposure of rats to 1R4F reference cigarette mainstream smoke: effect on prenatal and postnatal development.

@article{Gaworski2004InUA,
  title={In utero and lactation exposure of rats to 1R4F reference cigarette mainstream smoke: effect on prenatal and postnatal development.},
  author={Charles L Gaworski and Edward L Carmines and Ali Said Faqi and Narayanan Rajendran},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2004},
  volume={79 1},
  pages={157-69}
}
Childhood cognitive and behavioral deficits have been reported in children born to mothers who smoked during pregnancy (Institute of Medicine, 2001). To investigate these potential responses in an animal model, reproductive and neurotoxicity evaluations based on the U.S. FDA guidelines were used to examine the offspring of male and female Sprague-Dawley rats exposed 2 h/day, 7 days/week by nose-only inhalation to whole mainstream smoke total particulate matter (TPM). Concentrations of 150, 300… CONTINUE READING
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