In utero and in vitro exposure to beta-lactams impair kidney development in the rat.

@article{Nathanson2000InUA,
  title={In utero and in vitro exposure to beta-lactams impair kidney development in the rat.},
  author={S Nathanson and Evelyne Moreau and Claudie Merlet-B{\'e}nichou and Thierry Gilbert},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2000},
  volume={11 5},
  pages={874-84}
}
beta-Lactam antibiotics are widely used because of their lack of toxicity in humans. However, during pregnancy, exposure of the fetus is likely to occur because beta-lactam antibiotics cross the placenta. The potential adverse effects of two penicillins (ampicillin, amoxicillin) and of one cephalosporin (ceftriaxone) were examined in rat kidney development. Two experimental approaches were used: metanephros organ cultures to analyze the direct effect of the drug and maternal treatment to assess… CONTINUE READING
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