In utero and in vitro effects of benzene and its metabolites on erythroid differentiation and the role of reactive oxygen species.

@article{Badham2010InUA,
  title={In utero and in vitro effects of benzene and its metabolites on erythroid differentiation and the role of reactive oxygen species.},
  author={Helen J Badham and Louise M Winn},
  journal={Toxicology and applied pharmacology},
  year={2010},
  volume={244 3},
  pages={273-9}
}
Benzene is a ubiquitous occupational and environmental toxicant. Exposures to benzene both prenatally and during adulthood are associated with the development of disorders such as aplastic anemia and leukemia. Mechanisms of benzene toxicity are unknown; however, generation of reactive oxygen species (ROS) by benzene metabolites may play a role. Little is known regarding the effects of benzene metabolites on erythropoiesis. Therefore, to determine the effects of in utero exposure to benzene on… CONTINUE READING

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