In utero and acute exposure to benzene: investigation of DNA double-strand breaks and DNA recombination in mice.

@article{Lau2009InUA,
  title={In utero and acute exposure to benzene: investigation of DNA double-strand breaks and DNA recombination in mice.},
  author={Annette Anling Lau and Christine Lea Belanger and Louise M Winn},
  journal={Mutation research},
  year={2009},
  volume={676 1-2},
  pages={
          74-82
        }
}
Benzene, a ubiquitous pollutant, has been identified as a human leukemogen and early exposure to environmental carcinogens such as benzene has been linked to childhood leukemia. It is known that genotoxic agents can increase the frequency of DNA double-strand breaks (DSBs), which can initiate DNA recombinational repair mechanisms. In this study we investigated the induction of micronuclei, the formation of gamma-H2A.X as a marker of DNA DSBs, and the induction of somatic DNA recombination… CONTINUE READING
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