In utero administration of Ad5 and AAV pseudotypes to the fetal brain leads to efficient, widespread and long-term gene expression

@article{Rahim2012InUA,
  title={In utero administration of Ad5 and AAV pseudotypes to the fetal brain leads to efficient, widespread and long-term gene expression},
  author={Ahad A Rahim and Andrew M. S. Wong and Samira Ahmadi and Klemens Hoefer and Suzanne M. K. Buckley and David A. Hughes and Amit Nathwani and Audrey H Baker and John H Mcvey and Jon D. Cooper and Simon N Waddington},
  journal={Gene Therapy},
  year={2012},
  volume={19},
  pages={936-946}
}
The efficient delivery of genetic material to the developing fetal brain represents a powerful research tool and a means to supply therapy in a number of neonatal lethal neurological disorders. In this study, we have delivered vectors based upon adenovirus serotype 5 (Ad5) and adeno-associated virus (AAV) pseudotypes 2/5, 2/8 and 2/9 expressing green fluorescent protein to the E16 fetal mouse brain. One month post injection, widespread caudal to rostral transduction of neural cells was observed… CONTINUE READING
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