In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes.

@article{Uematsu1988InTM,
  title={In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes.},
  author={Yasushi Uematsu and Stephan Ryser and Zlatko Dembic and Peter Borgulya and Paul J. A. Krimpenfort and Anton Berns and Harald von Boehmer and Michael Steinmetz},
  journal={Cell},
  year={1988},
  volume={52 6},
  pages={831-41}
}
Transgenic mice were constructed with a functional T cell receptor beta gene. Transcription of the introduced gene is largely confined to T cells, but low levels of transcripts are also seen in B cells and in other tissues. Serological analyses show that most, if not all, of the T lymphocytes express the transgenic beta chain on the cell surface and lack beta chains encoded by endogenous beta genes. Molecular genetic analyses of uncloned and cloned T lymphocytes demonstrate that rearrangement… CONTINUE READING

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