In the sense of transcription regulation by G-quadruplexes: asymmetric effects in sense and antisense strands.

@article{Agarwal2014InTS,
  title={In the sense of transcription regulation by G-quadruplexes: asymmetric effects in sense and antisense strands.},
  author={Tani Agarwal and Saumya Roy and Santosh Kumar and Tushar Kanti Chakraborty and Souvik Maiti},
  journal={Biochemistry},
  year={2014},
  volume={53 23},
  pages={3711-8}
}
G-Quadruplexes occupy important regulatory regions in the genome. DNA G-quadruplexes in the promoter regions and RNA quadruplexes in the UTRs (untranslated regions) have been individually studied and variously implicated at different regulatory levels of gene expression. However, the formation of G-quadruplexes in the sense and antisense strands and their corresponding roles in gene regulation have not been studied in much detail. In the present study, we have elucidated the effect of strand… CONTINUE READING