In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase.

@article{Blttler2007InTR,
  title={In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase.},
  author={Sharon M Bl{\"a}ttler and Franck Rencurel and Michel Rene Kaufmann and Urs A. Meyer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 3},
  pages={1045-50}
}
Transcriptional activation of cytochrome P450 (CYP) genes and various drug metabolizing enzymes by the prototypical inducer phenobarbital (PB) and many other drugs and chemicals is an adaptive response of the organism to exposure to xenobiotics. The response to PB is mediated by the nuclear receptor constitutive androstane receptor (CAR), whereas the chicken xenobiotic receptor (CXR) has been characterized as the PB mediator in chicken hepatocytes. Our previous results suggested an involvement… CONTINUE READING