In the mind or in the brain? Scientific evidence for central sensitisation in chronic fatigue syndrome

  title={In the mind or in the brain? Scientific evidence for central sensitisation in chronic fatigue syndrome},
  author={Jo Nijs and Mira Meeus and Jessica Van Oosterwijck and Kelly Ickmans and Greta Moorkens and Guy H Hans and Luc S. De Clerck},
  journal={European Journal of Clinical Investigation},
Eur J Clin Invest 2011 

How to exercise people with chronic fatigue syndrome: evidence‐based practice guidelines

Eur J Clin Invest 2012; 42 (10): 1136–1144

The long wait for a breakthrough in chronic fatigue syndrome

Not over yet

Influence of Morphine and Naloxone on Pain Modulation in Rheumatoid Arthritis, Chronic Fatigue Syndrome/Fibromyalgia, and Controls: A Double‐Blind, Randomized, Placebo‐Controlled, Cross‐Over Study

  • L. HermansJ. Nijs M. Meeus
  • Medicine, Psychology
    Pain practice : the official journal of World Institute of Pain
  • 2018
Impaired pain inhibitory and enhanced pain facilitatory mechanisms are repeatedly reported in patients with central sensitization pain. However, the exact effects of frequently prescribed opioids on

Clinical characteristics of a novel subgroup of chronic fatigue syndrome patients with postural orthostatic tachycardia syndrome

A significant proportion of patients with chronic fatigue syndrome (CFS) also have postural orthostatic tachycardia syndrome (POTS). We aimed to characterize these patients and differentiate them

MicroRNAs as Biomarkers of Pain Intensity in Patients With Chronic Fatigue Syndrome

This study evaluated a set of miRNAs as diagnostic biomarkers of pain intensity in adolescents with chronic fatigue syndrome and correlated the expression of thesemiRNAs with the levels of inflammatory markers and pain‐related comorbidities in adolescence with CFS and healthy controls.

Exercise therapy for chronic fatigue syndrome (individual patient data)

To assess the effects of exercise therapy, alone and in combination, for people with chronic fatigue syndrome compared with treatment as usual control conditions and other interventions (psychological therapies, pharmacological treatment).

DNA Methylation and Brain‐Derived Neurotrophic Factor Expression Account for Symptoms and Widespread Hyperalgesia in Patients With Chronic Fatigue Syndrome and Comorbid Fibromyalgia

The role of brain‐derived neurotrophic factor genetics, epigenetics, and protein expression in patients with both CFS and comorbid fibromyalgia is explored.

Investigation of naturalistic sleep/wake behaviour in myalgic encephaloyelitis/chronic fatigue syndrome

The aim of this study was to compare sleep parameters in people with and without ME/CFS using self-report and actigraphy.

Exploring pain mechanisms in hypermobile Ehlers‐Danlos syndrome: A case–control study

The hypermobile type of Ehlers‐Danlos syndrome is a heritable connective tissue disorder, associated with joint hypermobility and prominent chronic pain, and the underlying mechanisms are still poorly understood.



Chronic Fatigue Syndrome and the Central Nervous System

It is suggested that the focal point of chronic fatigue syndrome research should be transferred to the central nervous system.

Cognitive–behavioral therapy attenuates nociceptive responding in patients with fibromyalgia: A pilot study

To explore the possibility that cognitive–behavioral therapy (CBT) influences fibromyalgia symptoms via descending inhibition of nociception, we evaluated the effects of CBT on the nociceptive

Reduction of serotonin transporters of patients with chronic fatigue syndrome

The density of serotonin transporters in the brain, as determined by using a radiotracer, was significantly reduced in the rostral subdivision of the anterior cingulate as compared with that in normal volunteers.

Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome

There is evidence for a hypofunction of the hypothalamic-pituitary-adrenal (HPA) axis in a proportion of the patients with chronic fatigue syndrome (CFS), despite the negative studies and

COX-2 as a multifunctional neuronal modulator

  • N. Bazan
  • Biology, Medicine
    Nature Medicine
  • 2001
COX-2 is involved in prostaglandin synthesis and expressed throughout the nervous system, where it participates in pain sensitivity and in synaptic plasticity, and may be another important player in neural aspects of the inflammatory response.

Pain inhibition and postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: An experimental study

Pain inhibition and postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome.

Central sensitization: a biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome

The hypothesis that central sensitization is also responsible for the sustaining pain complaints in CFS is proposed, based on the hyperalgesia and allodynia reported in C FS, on the elevated concentrations of nitric oxide presented in the blood of CFS patients, in addition to the typical personality styles seen in Cfs and on the brain abnormalities shown on brain images.