In the clutches of proteoglycans: how does heparan sulfate regulate FGF binding?

@article{Rapraeger1995InTC,
  title={In the clutches of proteoglycans: how does heparan sulfate regulate FGF binding?},
  author={Alan C. Rapraeger},
  journal={Chemistry & biology},
  year={1995},
  volume={2 10},
  pages={645-9}
}
Fibroblast growth factors and their receptors bind to heparan sulfate glycosaminoglycans. This is thought to promote ligand-receptor binding and enhance signaling by promoting receptor multimerization. Synthetic mimetics designed to occupy these binding sites may provide the means to understand and to regulate FGF signaling. 

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Heparan Sulfate: Biosynthesis, Structure, and Function.

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