In the clinic. Clostridium difficile Infection.

  title={In the clinic. Clostridium difficile Infection.},
  author={Margaret Trexler Hessen},
  journal={Annals of internal medicine},
  volume={153 7},
  pages={ITC41-15; quiz ITC416}
Antibiotic-associated diarrhea was described in the 1950s. By 1978, Clostridium difficile had been established as the most common cause of infection, accounting for 15% to 25% of cases (1). The reported incidence and severity as measured by total mortality and colectomy rates rose steadily from 1993 to 2003 (2). A national survey in 2008 of 648 U.S. hospitals reported an overall C. difficile prevalence of 13.1 per 1000 inpatients (3). In the past decade, a strain with increased virulence has… CONTINUE READING