In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection.

@article{SchartonKersten1996InTA,
  title={In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection.},
  author={Tanya M. Scharton-Kersten and Thomas A. Wynn and Eric Y. Denkers and Serenada Bălă and E L Grunvald and Sara Hieny and Ricardo Tostes Gazzinelli and Alan Sher},
  journal={Journal of immunology},
  year={1996},
  volume={157 9},
  pages={4045-54}
}
The relationship between IFN-gamma and IL-12 in generating innate immune responses and resistance to acute Toxoplasma gondii infection was assessed in T. gondii-exposed IFN-gamma knockout (gko) mice. Gko mice, in contrast to wild-type (wt) animals, rapidly succumbed to infection with either the avirulent ME49 strain or, surprisingly, an attenuated temperature-sensitive mutant strain, ts4. Microscopic examination of peritoneal exudates from infected gko mice demonstrated that mortality is… CONTINUE READING
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