In the Zzz Zone: The Effects of Z-Drugs on Human Performance and Driving

  title={In the Zzz Zone: The Effects of Z-Drugs on Human Performance and Driving},
  author={Naren Gunja},
  journal={Journal of Medical Toxicology},
Despite their improved pharmacokinetic profile, the Z-drugs, zolpidem, zopiclone, and zaleplon, have a spectrum of adverse effects comparable to benzodiazepines. This review focuses on the impairment from Z-drugs on cognition, behavior, psychomotor performance, and driving ability. Z-drugs are short-acting GABA agonists that reduce sleep latency without disturbing sleep architecture. Bizarre behavioral effects have prompted warnings on the prescription, dispensation, and use of Z-drugs… CONTINUE READING
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