In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin.

@article{Macmillan2005InSM,
  title={In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin.},
  author={Debbi Macmillan and Susan L. Currie and Karen N. Bradley and Thomas C. Muir and John G. McCarron},
  journal={Journal of cell science},
  year={2005},
  volume={118 Pt 23},
  pages={5443-51}
}
Ca2+ release from the sarcoplasmic reticulum (SR) by the IP3 receptors (IP3Rs) crucially regulates diverse cell signalling processes from reproduction to apoptosis. Release from the IP3R may be modulated by endogenous proteins associated with the receptor, such as the 12 kDa FK506-binding protein (FKBP12), either directly or indirectly by inhibition of the phosphatase calcineurin. Here, we report that, in addition to calcineurin, FKPBs modulate release through the mammalian target of rapamycin… CONTINUE READING
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