In situ zymographic localisation of type II collagen degrading activity in osteoarthritic human articular cartilage.

Abstract

OBJECTIVES Chondrocytic matrix metalloproteinases (MMPs) are believed to be important in osteoarthritic cartilage degradation. The cartilage lesion of osteoarthritis (OA) is focal and often progressive. During its development chondrocytes differentially up and down regulate production of mRNA for individual MMPs. This observation has potential implications… (More)

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