In situ potentiometric method to evaluate bacterial outer membrane-permeabilizing ability of drugs: example using antiprotozoal diamidines.

Abstract

We introduced a new assay system, combining tyrocidine A and a K(+)-selective electrode, to evaluate the bacterial outer membrane-permeabilizing ability of drugs. Tyrocidine A, in the presence of an outer membrane permeabilizer, increased the permeability to K(+) of the cytoplasmic membrane of Escherichia coli, because this antibiotic could markedly… (More)
DOI: 10.1016/j.mimet.2012.09.033

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@article{Ando2012InSP, title={In situ potentiometric method to evaluate bacterial outer membrane-permeabilizing ability of drugs: example using antiprotozoal diamidines.}, author={Makoto Ando and Rie Kamei and Keiko Komagoe and Tsuyoshi Inoue and Keiichi Yamada and Takashi Katsu}, journal={Journal of microbiological methods}, year={2012}, volume={91 3}, pages={497-500} }