In situ nucleic acid hybridization of cytokines in primary biliary cirrhosis: predominance of the Th1 subset.

@article{Harada1997InSN,
  title={In situ nucleic acid hybridization of cytokines in primary biliary cirrhosis: predominance of the Th1 subset.},
  author={Kenichi Harada and Judy Van de Water and Patrick S. C. Leung and Ross L Coppel and Aftab A Ansari and Yasuni Nakanuma and M Eric Gershwin},
  journal={Hepatology},
  year={1997},
  volume={25 4},
  pages={791-6}
}
Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by destruction of the intrahepatic bile ducts. It is generally believed that cellular immune mechanisms, particularly involving T cells, result in this bile duct damage. The relative strength of Th1 and Th2 responses has recently been proposed to be an important factor in the pathophysiology of various autoimmune diseases. In this study, we have attempted to identify the Th subset balance in PBC, by detection of… CONTINUE READING
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