In situ localization of type III and type IV collagen-expressing cells in human diabetic nephropathy.

@article{Razzaque1994InSL,
  title={In situ localization of type III and type IV collagen-expressing cells in human diabetic nephropathy.},
  author={Mohammed Shawkat Razzaque and Takehiko Koji and Takashi Taguchi and Takashi Harada and Paul K. Nakane},
  journal={The Journal of pathology},
  year={1994},
  volume={174 2},
  pages={131-8}
}
Nodular intercapillary glomerulosclerosis is the most typical lesion of diabetic nephropathy (DN) and is characterized by increased extracellular matrix (ECM) and amorphous masses of mesangial matrix. The local exaggeration of these deposits results in the formation of the typical diabetic nodule. To clarify the composition of the ECM of sclerotic lesions in DN, we investigated the distribution of type III and type IV collagens and their mRNAs by immunohistochemistry and in situ hybridization… CONTINUE READING

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