In situ localization of ribosomal RNAs is a reliable reference for hybridizable RNA in tissue sections.

@article{Yoshii1995InSL,
  title={In situ localization of ribosomal RNAs is a reliable reference for hybridizable RNA in tissue sections.},
  author={Akihiro Yoshii and Takehiko Koji and Nakaaki Ohsawa and Paul K. Nakane},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={1995},
  volume={43 3},
  pages={321-7}
}
Assessments of RNA integrity and its hybridizability are essential for successful implementation of in situ hybridization (ISH) for mRNA or viral RNA, particularly when paraffin-embedded specimens from surgical, biopsy, and autopsy cases are used. In this study, we examined the suitability of ISH of 28S ribosomal RNA (rRNA) for this purpose. Oligo-DNA with nucleotide sequences complementary to a well-conserved segment of 28S rRNA with auxiliary adenine-thymine-thymine (ATT) repeats at the 3… CONTINUE READING

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