In situ localization of mitochondrial DNA replication in intact mammalian cells

@article{Davis1996InSL,
  title={In situ localization of mitochondrial DNA replication in intact
 mammalian cells},
  author={Anson F Davis and D. A. Clayton},
  journal={The Journal of Cell Biology},
  year={1996},
  volume={135},
  pages={883 - 893}
}
Nearly all of the known activities required for mitochondrial DNA (mtDNA) replication and expression are nuclear-encoded gene products, necessitating communication between these two physically distinct intracellular compartments. A significant amount of both general and specific biochemical information about mtDNA replication in mammalian cells has been known for almost two decades. Early studies achieved selective incorporation of the thymidine analog 5-Bromo-2-deoxy-Uridine (BrdU) into mtDNA… CONTINUE READING