In situ localization of collagen production by chondrocytes and osteoblasts in fracture callus.

@article{Sandberg1989InSL,
  title={In situ localization of collagen production by chondrocytes and osteoblasts in fracture callus.},
  author={Marta Sandberg and Hannu T. Aro and P Multim{\"a}ki and Heikki Aho and E. Vuorio},
  journal={The Journal of bone and joint surgery. American volume},
  year={1989},
  volume={71 1},
  pages={69-77}
}
An experimental model of fracture-healing was used to study the production of types-I and II collagen by in situ hybridization. The distribution of cartilage matrix in callus was determined by histochemical staining. Messenger RNA (mRNA) for cartilage-specific type-II collagen was detectable as early as the fifth day in a small number of cells that had acquired a chondrocyte phenotype but that also contained type-I collagen mRNA, suggesting an ongoing change in the expression of collagen genes… CONTINUE READING
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