In situ localization of C3 synthesis in experimental acute renal allograft rejection.

@article{Pratt2000InSL,
  title={In situ localization of C3 synthesis in experimental acute renal allograft rejection.},
  author={Julian R. Pratt and Keith Abe and Masaru Miyazaki and Wuding Zhou and Steven H Sacks},
  journal={The American journal of pathology},
  year={2000},
  volume={157 3},
  pages={825-31}
}
Recent evidence has implicated complement in renal transplant injury and identified the kidney as a source of complement components. We therefore investigated the local gene expression of complement component C3, pivotal to complement activation pathways and a mediator of inflammatory injury, in a rat renal transplant model. By reverse transcriptase-polymerase chain reaction, the expression of C3 mRNA increased in two phases. The first phase coincided with post-ischemic injury over 2 days post… CONTINUE READING
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