In situ imaging reveals different responses by naïve and memory CD8 T cells to late antigen presentation by lymph node DC after influenza virus infection.

@article{Khanna2008InSI,
  title={In situ imaging reveals different responses by na{\"i}ve and memory CD8 T cells to late antigen presentation by lymph node DC after influenza virus infection.},
  author={Kamal M Khanna and Carolina C Aguila and Jason M Redman and Jenny E Su{\'a}rez-Ram{\'i}rez and Leo Lefrançois and Linda S. Cauley},
  journal={European journal of immunology},
  year={2008},
  volume={38 12},
  pages={3304-15}
}
Pulmonary influenza infection causes prolonged lymph node hypertrophy while processed viral antigens continue to be presented to virus-specific CD8 T cells. We show that naïve, but not central/memory, nucleoprotein (NP)-specific CD8 T cells recognized antigen-bearing CD11b(+) DC in the draining lymph nodes more than 30 days after infection. After these late transfers, the naïve CD8 T cells underwent an abortive proliferative response in the mediastinal lymph node (MLN), where large clusters of… CONTINUE READING

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