In situ hybridization to somatic chromosomes in Drosophila.

  title={In situ hybridization to somatic chromosomes in Drosophila.},
  author={Abby F. Dernburg},
  journal={Cold Spring Harbor protocols},
  volume={2011 9}
In situ hybridization was originally developed as a technique for visualizing and physically mapping specific sequences on Drosophila melanogaster polytene chromosomes. Hybridization techniques can also be used to localize sequences on smaller, diploid chromosomes, such as condensed mitotic chromosomes. Variations of the method also allow the hybridization of probes to chromosomes within intact cells and tissues, rather than to chromosomes isolated from their cellular context and flattened on… CONTINUE READING
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