In situ hybridization of calcium/calmodulin dependent protein kinase II and tau mRNAs; species differences and relative preservation in Alzheimer's disease.

@article{Mah1992InSH,
  title={In situ hybridization of calcium/calmodulin dependent protein kinase II and tau mRNAs; species differences and relative preservation in Alzheimer's disease.},
  author={Vei H. Mah and Thomas A. Eskin and Ann M. Kazee and Laura Lapham and Gerald A. Higgins},
  journal={Brain research. Molecular brain research},
  year={1992},
  volume={12 1-3},
  pages={85-94}
}
Abnormal phosphorylation of the microtubule associated protein tau component of neurofibrillary tangles (NFTs) in Alzheimer's disease (AD) may result from alterations in protein kinase expression. Calcium/calmodulin dependent protein kinase II (CaM kinase II) has been shown to phosphorylate tau in vitro in such a way to decrease its electrophoretic mobility. A68, apparently a modified form of tau in AD brain, also shows abnormal phosphorylation and slower mobility than tau. To further examine… CONTINUE READING
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