In situ growth rates and biofilm development of Pseudomonas aeruginosa populations in chronic lung infections.

@article{Yang2008InSG,
  title={In situ growth rates and biofilm development of Pseudomonas aeruginosa populations in chronic lung infections.},
  author={Lei Yang and Janus Haagensen and Lars Jelsbak and Helle Krogh Johansen and Claus Sternberg and Niels H\oiby and Soeren Molin},
  journal={Journal of bacteriology},
  year={2008},
  volume={190 8},
  pages={2767-76}
}
The growth dynamics of bacterial pathogens within infected hosts are a fundamental but poorly understood feature of most infections. We have focused on the in situ distribution and growth characteristics of two prevailing and transmissible Pseudomonas aeruginosa clones that have caused chronic lung infections in cystic fibrosis (CF) patients for more than 20 years. We used fluorescence in situ hybridization (FISH) directly on sputum specimens to examine the spatial distribution of the infecting… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 81 extracted citations

Trace incorporation of heavy water reveals slow and heterogeneous pathogen growth rates in cystic fibrosis sputum.

Proceedings of the National Academy of Sciences of the United States of America • 2016
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 57 references

Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients.

Proceedings of the National Academy of Sciences of the United States of America • 2006
View 2 Excerpts

Cystic VOL

K. L. Palmer, L. M. Mashburn, P. K. Singh, M. Whiteley
J. Bacteriol • 2005
View 1 Excerpt

New insight into the pathogenesis and epidemiology of Pseudomonas aeruginosa infection in cystic fibrosis, p. 11–25

N. Høiby
Proceedings of the 4 th Elzen - veld workshop on infectious diseases : non - fermenting Gram - negative bacilli : microbiological and clinical challenges • 2005
View 3 Excerpts

Similar Papers

Loading similar papers…