In situ gelling systems: a strategy to improve the bioavailability of ophthalmic pharmaceutical formulations.

@article{Almeida2014InSG,
  title={In situ gelling systems: a strategy to improve the bioavailability of ophthalmic pharmaceutical formulations.},
  author={Hugo J. R. Almeida and Maria Helena Amaral and Paulo Lob{\~a}o and Jos{\'e} Manuel Sousa Lobo},
  journal={Drug discovery today},
  year={2014},
  volume={19 4},
  pages={
          400-12
        }
}
The low therapeutic efficacy exhibited by conventional ophthalmic solutions owing to precorneal elimination of the drug, drainage by gravity, nasolacrimal drainage, conjunctival absorption, and the absence of controlled release and of bioadhesive properties, can be overcome by the use of in situ gelling systems. The combination in the same formulation of different in situ gelling polymers with different stimuli-responsiveness mechanisms exploiting the unique physicochemical characteristics of… CONTINUE READING
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