In situ gelling pectin formulations for oral drug delivery at high gastric pH.

@article{Itoh2007InSG,
  title={In situ gelling pectin formulations for oral drug delivery at high gastric pH.},
  author={Kunihiko Itoh and Tomohiro Hirayama and Akie Takahashi and Wataru Kubo and Shozo Miyazaki and Masatake Dairaku and Mitsuo Togashi and Ryozo Mikami and David Attwood},
  journal={International journal of pharmaceutics},
  year={2007},
  volume={335 1-2},
  pages={90-6}
}
The aim of the study was to compare the gelation and drug release characteristics of formulations of pectin with high (31%) and low (9%) degrees of methoxylation over a wide pH range (pH 1.2-5.0). Dilute solutions of pectin (1.5%, w/v) containing complexed calcium ions formed gels in vitro at low pH (pH<2.5) as a consequence of cross-linking of the galacturonic chains by calcium ions released from the complex, but the efficiency of gelation was significantly reduced with increase of pH because… CONTINUE READING

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