In situ-gelling gellan formulations as vehicles for oral drug delivery.

  title={In situ-gelling gellan formulations as vehicles for oral drug delivery.},
  author={Shozo Miyazaki and Hidehisa Aoyama and Naoko Kawasaki and Wataru Kubo and David Attwood},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={60 2-3},
Gels formed in situ following oral administration of 1% (w/v) aqueous solutions of gellan to rats and rabbits were evaluated as sustained-release vehicles. The formulation contained calcium ions in complexed form, the release of which in the acidic environment of the stomach caused gelation of the gellan gum. The in vitro release of theophylline from the rigid gellan gels followed root-time kinetics over a period of 6 h. Plasma levels of theophylline after oral administration of gellan… CONTINUE READING
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