In situ gelation for cell immobilization and culture in alginate foam scaffolds.

@article{Andersen2014InSG,
  title={In situ gelation for cell immobilization and culture in alginate foam scaffolds.},
  author={Therese Andersen and Christine Markussen and Michael Dornish and Helene Heier-Baardson and Jan Egil Melvik and Eben Alsberg and Bj\orn Christensen},
  journal={Tissue engineering. Part A},
  year={2014},
  volume={20 3-4},
  pages={600-10}
}
Essential cellular functions are often lost under culture in traditional two-dimensional (2D) systems. Therefore, biologically more realistic three-dimensional (3D) cell culture systems are needed that provide mechanical and biochemical cues which may otherwise be unavailable in 2D. For the present study, an alginate-based hydrogel system was used in which cells in an alginate solution were seeded onto dried alginate foams. A uniform distribution of NIH:3T3 and NHIK 3025 cells entrapped within… CONTINUE READING
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