In situ forming interpenetrating hydrogels of hyaluronic acid hybridized with iron oxide nanoparticles.

Abstract

Four derivatives of hyaluronic acid (HA) bearing thiol (HA-SH), hydrazide (HA-hy), 2-dithiopyridyl (HA-SSPy), and aldehyde groups (HA-al) respectively were synthesized. Thiol and 2-dithiopyridyl as well as hydrazide and aldehyde make up two chemically orthogonal pairs of chemo-selective functionalities that allow in situ formation of interpenetrating (IPN… (More)
DOI: 10.1039/c5bm00150a

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