In situ expression of B7 and CD28 receptor families in human malignant melanoma: relevance for T-cell-mediated anti-tumor immunity.

@article{Denfeld1995InSE,
  title={In situ expression of B7 and CD28 receptor families in human malignant melanoma: relevance for T-cell-mediated anti-tumor immunity.},
  author={Ralf W Denfeld and Arne Dietrich and Christine Wuttig and Ervin Tanczos and Johannes Martin Weiss and Wolfgang Vanscheidt and Erwin Sch{\"o}pf and J C Simon},
  journal={International journal of cancer},
  year={1995},
  volume={62 3},
  pages={259-65}
}
Work in animal models has suggested that interactions of members of the B7 receptor family (e.g., B7-1, B7-2) on tumor cells with their ligands CD28 and CTLA-4 on cytotoxic T cells (CTL) are important for the induction of anti-tumor immunity against malignant melanoma (MM). To determine whether these molecules are of relevance for CTL responses against human MM, we studied the expression of B7-1, B7-2, CD28 and CTLA-4 in primary tumors of MM (PMM), MM metastases (MMM) and benign melanocytic… CONTINUE READING