In situ expansion of T cells that recognize distinct self-antigens sustains autoimmunity in the CNS.

@article{Ramadan2016InSE,
  title={In situ expansion of T cells that recognize distinct self-antigens sustains autoimmunity in the CNS.},
  author={Abdulraouf Ramadan and Liliana E Lucca and Nad{\`e}ge Carri{\'e} and Sabine Desbois and Pierre-Paul Axisa and M. Ethtesham Hayder and Jan Niklas Bauer and Roland S Liblau and Lennart T. Mars},
  journal={Brain : a journal of neurology},
  year={2016},
  volume={139 Pt 5},
  pages={1433-46}
}
Polyspecific T cells recognizing multiple distinct self-antigens have been identified in multiple sclerosis and other organ-specific autoimmune diseases, but their pathophysiological relevance remains undetermined. Using a mouse model of multiple sclerosis, we show that autoimmune encephalomyelitis induction is strictly dependent on reactivation of pathogenic T cells by a peptide (35-55) derived from myelin oligodendrocyte glycoprotein (MOG). This disease-inducing response wanes after onset… CONTINUE READING
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