In situ detection of polymerase chain reaction-amplified HIV-1 nucleic acids in skeletal muscle in patients with myopathy.

@article{Seidman1994InSD,
  title={In situ detection of polymerase chain reaction-amplified HIV-1 nucleic acids in skeletal muscle in patients with myopathy.},
  author={Roberta J. Seidman and Nancy S. Peress and Gerard J Nuovo},
  journal={Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc},
  year={1994},
  volume={7 3},
  pages={369-75}
}
The purpose of this study was to determine if the myopathy that commonly occurs in patients with AIDS is associated with active HIV-1 infection in the muscle tissues. Seven muscle biopsies from patients infected by HIV-1 and six controls were tested for HIV-1 DNA and RNA using polymerase chain reaction in situ hybridization and reverse transcriptase in situ polymerase chain reaction. HIV-1 DNA was detected in rare cells in only one case by standard in situ hybridization. However, after… CONTINUE READING
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