In situ detection of frequent and active infection of human cytomegalovirus in inflammatory abdominal aortic aneurysms: possible pathogenic role in sustained chronic inflammatory reaction.

@article{Yonemitsu1996InSD,
  title={In situ detection of frequent and active infection of human cytomegalovirus in inflammatory abdominal aortic aneurysms: possible pathogenic role in sustained chronic inflammatory reaction.},
  author={Yoshikazu Yonemitsu and Koji Nakagawa and Shinji Tanaka and Ryoichi Mori and Keishi Sugimachi and Katsuo Sueishi},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1996},
  volume={74 4},
  pages={
          723-36
        }
}
Inflammatory abdominal aortic aneurysm (IAAA) is histopathologically characterized by extensive adventitial fibrosis, mononuclear cell infiltration with lymph follicle formation, and severe atheromatous changes in the aneurysmal wall. We previously reported a frequent prevalence and immediate early gene expression of human cytomegalovirus (CMV) in IAAA by solution-phase PCR and reverse transcription PCR, respectively, and suggested that this virus might play a role in chronic inflammatory… CONTINUE READING
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